Description

1-(Difluoromethyl)-4-Iodobenzene is a specialized fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique reactivity profile, where the difluoromethyl and iodo substituents serve as versatile handles for further functionalization, enabling the construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability, bioavailability, or receptor binding.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can impart favorable biological activity and environmental persistence profiles.
• Material Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The aryl iodide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form biaryl or extended conjugated systems.
• Fluorine Chemistry Exploration: Utilized in methodological studies to investigate new reactions involving the difluoromethyl group, such as radical additions or nucleophilic substitutions.
• Labeling and Tracer Development: The iodine atom can be replaced with radioactive isotopes (e.g., I-125) for use in radiolabeling and positron emission tomography (PET) tracer development.

Basic Information

Product Name	1-(Difluoromethyl)-4-Iodobenzene
CAS No.	1214372-82-3
Molecular Formula	C7H5F2I
Molecular Weight	253.92 g/mol
Synonyms	4-Iodobenzyl Difluoride; p-Iodobenzyl Difluoride; (4-Iodophenyl)difluoromethane; 4-(Difluoromethyl)iodobenzene; 1-Iodo-4-(difluoromethyl)benzene; α,α-Difluoro-4-iodotoluene; DFIB
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-4-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.