Description

1-(Difluoromethyl)-3-Iodobenzene is a specialized fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoromethyl and iodo substituents, makes it a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for applications in cross-coupling reactions, fluorination chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including potential kinase inhibitors and CNS-active compounds.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a building block for fluorinated liquid crystals, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to create biaryl and other complex structures.
• Fluorine Chemistry: The difluoromethyl group can be utilized for further functionalization or as a bioisostere in medicinal chemistry programs.
• R&D and Process Chemistry: Essential for route scouting, analog synthesis, and scale-up studies in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	1-(Difluoromethyl)-3-Iodobenzene
CAS No.	1214372-71-0
Molecular Formula	C7H5F2I
Molecular Weight	253.92 g/mol
Synonyms	3-Iodobenzyl Difluoride; m-Iodo-α,α-difluorotoluene; 3-Iodo-α,α-difluorotoluene; (3-Iodophenyl)difluoromethane; 1-Iodo-3-(difluoromethyl)benzene; m-(Difluoromethyl)iodobenzene; 3-(Difluoromethyl)iodobenzene; 1214372-71-0
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-3-Iodobenzene is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.