Description

2-Chloro-4-(Difluoromethyl)-1-Fluorobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in its unique substitution pattern, which makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl and chloro groups contribute to biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its fluorine content.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new fluorination methodologies and the effects of fluorine substitution.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies engaged in custom synthesis projects for clients in life sciences.

Basic Information

Product Name	2-Chloro-4-(Difluoromethyl)-1-Fluorobenzene
CAS No.	1214372-57-2
Molecular Formula	C7H4ClF3
Molecular Weight	180.55 g/mol
Synonyms	1-Fluoro-2-chloro-4-(difluoromethyl)benzene; 2-Chloro-α,α-difluoro-4-fluorotoluene; 4-(Difluoromethyl)-1-fluoro-2-chlorobenzene; 2-Chloro-4-difluoromethyl-1-fluorobenzene; 2-Chloro-4-(difluoromethyl)fluorobenzene; Benzene, 2-chloro-4-(difluoromethyl)-1-fluoro-; (2-Chloro-4-(difluoromethyl)phenyl) fluoride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(Difluoromethyl)-1-Fluorobenzene is manufactured and controlled under a strict quality management system. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) with batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.