Description

3-Bromo-2-Fluorobenzenesulfonylchloride is a high-purity, specialized organosulfur compound that serves as a critical building block in advanced organic synthesis. Its unique halogenated and sulfonyl chloride functional groups make it an indispensable reagent for introducing specific molecular motifs with high selectivity. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, complex ligands, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides with tailored activity profiles.
• Material Science Research: Building block for creating functional polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and protein labeling.
• Cross-Coupling Reactions: Serves as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Sulfonylation Agent: Used to introduce the benzenesulfonyl moiety into target molecules, creating sulfones and sulfonamides under mild conditions.

Basic Information

Product Name	3-Bromo-2-Fluorobenzenesulfonylchloride
CAS No.	1214372-19-6
Molecular Formula	C6H3BrClFO2S
Molecular Weight	273.51 g/mol
Synonyms	2-Fluoro-3-bromobenzenesulfonyl chloride; 3-Bromo-2-fluorobenzene-1-sulfonyl chloride; 1-Bromo-2-fluoro-6-(chlorosulfonyl)benzene; Benzenesulfonyl chloride, 3-bromo-2-fluoro-; 1214372-19-6; 3-Br-2-F-PhSO2Cl
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-Fluorobenzenesulfonylchloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO 9001 standards for reliable sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.