Description

3-(Difluoromethoxy)-4-Fluorobenzaldehyde is a high-purity fluorinated aromatic aldehyde building block, essential for advanced organic synthesis. Its unique difluoromethoxy and fluorine substituents make it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily required by researchers and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: The aldehyde functional group makes it a suitable substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Custom Synthesis & R&D: A valuable reagent for contract research organizations (CROs) and academic institutions exploring new fluorinated chemical entities.

Basic Information

Product Name	3-(Difluoromethoxy)-4-Fluorobenzaldehyde
CAS No.	1214367-20-0
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	4-Fluoro-3-(difluoromethoxy)benzaldehyde; 3-(Difluoromethoxy)-4-fluorobenzenecarboxaldehyde; 4-Fluoro-α,α-difluoroanisole-3-carboxaldehyde; Benzaldehyde, 3-(difluoromethoxy)-4-fluoro-; 1214367-20-0; 4-Fluoro-3-difluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethoxy)-4-Fluorobenzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.5%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.