Description

5-(Difluoromethyl)-2-Fluorobenzotrifluoride is a high-value fluorinated aromatic building block, essential for introducing multiple fluorine atoms into complex molecular architectures. Its unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where specific electronic and steric properties are required. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoromethyl and trifluoromethyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing components in electronic display materials, improving performance and durability.
• Polymer & Resin Modifier: Imparts desirable properties like chemical resistance and low surface energy into specialty polymers and coatings.
• Organic Synthesis Reagent: A versatile reagent for introducing fluorinated motifs in cross-coupling reactions and other catalytic transformations.

Basic Information

Product Name	5-(Difluoromethyl)-2-Fluorobenzotrifluoride
CAS No.	1214364-78-9
Molecular Formula	C8H3F6
Molecular Weight	228.10 g/mol
Synonyms	2-Fluoro-5-(difluoromethyl)benzotrifluoride; 1-(Difluoromethyl)-4-fluoro-2-(trifluoromethyl)benzene; Benzene, 1-(difluoromethyl)-4-fluoro-2-(trifluoromethyl)-; 5-(Difluoromethyl)-2-fluorobenzotrifluoride; α,α-Difluoro-4-fluoro-2-(trifluoromethyl)toluene
EINECS	Contact for details

Quality Control

Every batch of 5-(Difluoromethyl)-2-Fluorobenzotrifluoride is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by GC/HPLC and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (GC / HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.