Description

Methyl-2,5-Difluoropyridine-3-Carboxylate CAS NO 1214362-39-6 is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise introduction of fluorine atoms and a versatile ester functional group into complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoropyridine moiety can improve metabolic stability and bioavailability.
• Material Science Precursor: Acts as a starting material for synthesizing functionalized ligands and complex organic frameworks used in catalysis and electronic materials.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships (SAR) and for the synthesis of fluorinated analogs in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored compounds for client projects.

Basic Information

Product Name	Methyl-2,5-Difluoropyridine-3-Carboxylate
CAS No.	1214362-39-6
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	Methyl 2,5-Difluoropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2,5-difluoro-, methyl ester; 2,5-Difluoronicotinic acid methyl ester; Methyl 2,5-difluoronicotinate; 1214362-39-6; Methyl 2,5-difluoro-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl-2,5-Difluoropyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.