Description

2-(Difluoromethoxy)-5-Fluoropyridine is a high-value fluorinated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique difluoromethoxy and fluoro substituents make it an essential intermediate for constructing complex molecules with enhanced metabolic stability and bioavailability. This compound is primarily sought by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in catalysis and as a building block for functional materials.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new fluorination methodologies and creating compound libraries for screening.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Fluoropyridine
CAS No.	1214360-67-4
Molecular Formula	C6H4F3NO
Molecular Weight	163.10 g/mol
Synonyms	5-Fluoro-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-fluoropyridine; 5-Fluoro-2-(difluoromethoxy)pyridine; Pyridine, 5-fluoro-2-(difluoromethoxy)-; 1214360-67-4
EINECS	Contact for details

Quality Control

We supply 2-(Difluoromethoxy)-5-Fluoropyridine with a standard purity of ≥97% (by HPLC), tailored to meet the stringent requirements of research and process development. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.