Description

1-(Difluoromethyl)-3-(Trifluoromethyl)Benzene is a high-value, multi-fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both difluoromethyl and trifluoromethyl substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers, liquid crystals, and electronic materials requiring specific dielectric properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a source of fluorinated aryl groups in medicinal and process chemistry research.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and developing new fluorination methodologies in academic and industrial labs.

Basic Information

Product Name	1-(Difluoromethyl)-3-(Trifluoromethyl)Benzene
CAS No.	1214358-15-2
Molecular Formula	C9H5F5
Molecular Weight	208.13 g/mol
Synonyms	3-(Trifluoromethyl)benzylidene difluoride; α,α-Difluoro-3-(trifluoromethyl)toluene; 1-(Difluoromethyl)-3-(trifluoromethyl)benzene; 3-(Trifluoromethyl)benzaldehyde difluoride; m-(Trifluoromethyl)benzylidene difluoride; (3-(Trifluoromethyl)phenyl)difluoromethane; Benzene, 1-(difluoromethyl)-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. The compound is compatible with most organic solvents but should be kept under an inert atmosphere for extended periods to prevent moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.