Description

5-Bromo-2-(Difluoromethyl)Benzotrifluoride is a high-value, multi-functional fluorinated aromatic building block. This compound is engineered to introduce both bromine and trifluoromethyl/difluoromethyl motifs, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine-containing groups enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Library Building: Essential for medicinal chemistry teams building focused libraries to explore structure-activity relationships (SAR) around fluorinated scaffolds.

Basic Information

Product Name	5-Bromo-2-(Difluoromethyl)Benzotrifluoride
CAS No.	1214352-15-4
Molecular Formula	C8H3BrF5
Molecular Weight	272.99 g/mol
Synonyms	1-Bromo-4-(difluoromethyl)-2-(trifluoromethyl)benzene; 2-Bromo-5-(difluoromethyl)benzotrifluoride; 5-Bromo-α,α-difluoro-2-(trifluoromethyl)benzenemethanol (related); Benzene, 1-bromo-4-(difluoromethyl)-2-(trifluoromethyl)-; 5-Bromo-2-(difluoromethyl)benzotrifluoride; 1214352-15-4 (CAS Index Name)
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-(Difluoromethyl)Benzotrifluoride is produced and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets the exacting standards required for advanced synthetic applications. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place, away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.