Description

2-Fluoro-5-Phenylpyridine-3-Carboxylic Acid is a high-value fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a fluorine substituent on the pyridine ring, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Ligand Synthesis: Serves as a precursor for creating complex ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the construction of fluorinated probes for studying biological processes and protein interactions.
• Advanced Material Development: A building block for organic electronic materials and liquid crystals due to its rigid, conjugated structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-Fluoro-5-Phenylpyridine-3-Carboxylic Acid
CAS No.	1214349-86-6
Molecular Formula	C₁₂H₈FNO₂
Molecular Weight	217.20 g/mol
Synonyms	2-Fluoro-5-phenylnicotinic acid; 3-Pyridinecarboxylic acid, 2-fluoro-5-phenyl-; 5-Phenyl-2-fluoropyridine-3-carboxylic acid; 2-Fluoro-5-phenyl-3-pyridinecarboxylic acid; 1214349-86-6; 2-Fluoro-5-phenyl-pyridine-3-carboxylic acid; 2-Fluoro-5-phenyl-3-carboxypyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Phenylpyridine-3-Carboxylic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.