Description

Methyl 5-Fluoro-2-Methoxyisonicotinate is a high-purity fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in drug discovery and development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile synthon for further functionalization in medicinal chemistry and material science projects.
• Ligand and Catalyst Preparation: Utilized in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	Methyl 5-Fluoro-2-Methoxyisonicotinate
CAS No.	1214346-01-6
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	Methyl 5-fluoro-2-methoxypyridine-4-carboxylate; 5-Fluoro-2-methoxyisonicotinic acid methyl ester; 4-Pyridinecarboxylic acid, 5-fluoro-2-methoxy-, methyl ester; 2-Methoxy-5-fluoro-4-pyridinecarboxylic acid methyl ester; 5-Fluoro-2-methoxypyridine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Fluoro-2-Methoxyisonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.