Description

2-Fluoro-5-(Trifluoromethyl)Pyrimidine is a high-value fluorinated pyrimidine building block essential for advanced organic synthesis. This compound is prized for its ability to introduce both fluorine and a trifluoromethyl group, significantly altering the electronic and metabolic properties of target molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and CF3 groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty chemicals, liquid crystals, and advanced polymers requiring specific fluorinated aromatic systems.
• Cross-Coupling Reactions: An effective substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The fluorine atom at the 2-position is highly reactive, making it an excellent candidate for nucleophilic substitution to introduce diverse functional groups.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Pyrimidine
CAS No.	1214344-68-9
Molecular Formula	C5H2F4N2
Molecular Weight	166.08 g/mol
Synonyms	5-(Trifluoromethyl)-2-fluoropyrimidine; 2-Fluoro-5-trifluoromethylpyrimidine; Pyrimidine, 2-fluoro-5-(trifluoromethyl)-; 2-Fluoro-5-(trifluoromethyl)pyrimidine; 1214344-68-9
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its fluoride/strong alkali reactivity profile and highly volatile nature, keep away from incompatible materials and ensure containers are sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.