Description

5,6-Difluoro-Pyridin-3-Ylamine is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique difluoro-substituted pyridine core, which is essential for modulating the electronic properties, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Employed as a precursor for synthesizing functionalized ligands, organic semiconductors, and liquid crystal materials.
• Chemical Biology Probes: Useful for creating fluorescent tags or molecular probes to study biological processes and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up batches under cGMP conditions.

Basic Information

Product Name	5,6-Difluoro-Pyridin-3-Ylamine
CAS No.	1214344-65-6
Molecular Formula	C5H4F2N2
Molecular Weight	130.10 g/mol
Synonyms	3-Amino-5,6-difluoropyridine; 5,6-Difluoropyridin-3-amine; 5,6-Difluoro-3-pyridinamine; 3-Pyridinamine, 5,6-difluoro-; 5,6-Difluoro-3-aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 5,6-Difluoro-Pyridin-3-Ylamine is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.