Description

3-Bromo-5-Fluorobenzene-1-Sulfonyl Chloride is a high-purity, multi-functional aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual reactive sites—the sulfonyl chloride and halogenated aromatic ring—which enable precise molecular construction for complex target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct novel herbicidal and fungicidal agents by introducing the sulfonyl moiety into active molecules.
• Material Science: Building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its aromatic and halogenated structure.
• Chemical Biology Probes: Employed in the development of activity-based probes and labeling reagents for studying biological systems.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Sulfonylation Reagent: Used to introduce the sulfonyl group into amines, alcohols, and other nucleophiles to create sulfonamides, sulfonate esters, and sulfones.

Basic Information

Item	Detail
Product Name	3-Bromo-5-Fluorobenzene-1-Sulfonyl Chloride
CAS No.	1214342-44-5
Molecular Formula	C6H3BrClFO2S
Molecular Weight	273.51 g/mol
Synonyms	3-Bromo-5-fluorobenzenesulfonyl chloride; 1-Bromo-3-fluoro-5-(chlorosulfonyl)benzene; 5-Bromo-3-fluorobenzenesulfonyl chloride; Benzenesulfonyl chloride, 3-bromo-5-fluoro-; 3-Fluoro-5-bromobenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Fluorobenzene-1-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards, and comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and meet your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, amines, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.