Description

1-Bromo-4-(Chloromethyl)-2-(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic building block containing bromo, chloromethyl, and trifluoromethyl substituents. This compound matters for its unique reactivity profile, enabling precise synthetic transformations in advanced chemical synthesis. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated or halogenated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a versatile starting material for constructing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals, polymers, and organic electronic components, where its substituents allow for fine-tuning of physical properties.
• Cross-Coupling Reactions: The bromo and chloromethyl groups make it an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to build complex molecular architectures.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl group into target molecules, a common strategy in modern medicinal and agrochemical design.

Basic Information

Product Name	1-Bromo-4-(Chloromethyl)-2-(Trifluoromethyl)Benzene
CAS No.	1214339-27-1
Molecular Formula	C8H5BrClF3
Molecular Weight	273.48 g/mol
Synonyms	4-Bromo-α-chloro-α,α,α-trifluoro-o-xylene; 2-(Trifluoromethyl)-4-bromobenzyl chloride; 1-Bromo-4-(chloromethyl)-2-(trifluoromethyl)benzene; 4-Bromo-2-(trifluoromethyl)benzyl chloride; α-Chloro-4-bromo-α,α,α-trifluoro-o-xylene; (4-Bromo-2-(trifluoromethyl)phenyl)methyl chloride
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Chloromethyl)-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The compound may be moisture-sensitive; keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.