Description

2-Bromo-1-(Difluoromethyl)-3-Fluorobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, featuring bromine and fluorine substituents that enable precise functionalization and modulate electronic properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine and difluoromethyl groups on aromatic systems in medicinal and synthetic chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-Bromo-1-(Difluoromethyl)-3-Fluorobenzene
CAS No.	1214338-27-8
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	1-Bromo-2-(difluoromethyl)-4-fluorobenzene; 2-Bromo-α,α-difluoro-3-fluorotoluene; 3-Fluoro-2-bromobenzylidene difluoride; (2-Bromo-3-fluorophenyl)difluoromethane; Benzene, 2-bromo-1-(difluoromethyl)-3-fluoro-; CAS 1214338-27-8
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(Difluoromethyl)-3-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.