Description

4-Chloro-1-(Difluoromethyl)-2-Fluorobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique substitution pattern, which makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly where the introduction of fluorine atoms is critical for enhancing metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where fluorinated motifs improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes.
• Functional Material Development: Employed in polymer and advanced material science to create fluorinated polymers with enhanced chemical resistance and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-Chloro-1-(Difluoromethyl)-2-Fluorobenzene
CAS No.	1214337-46-8
Molecular Formula	C7H4ClF3
Molecular Weight	180.56 g/mol
Synonyms	2-Fluoro-4-chloro-α,α-difluorotoluene; 1-Chloro-4-(difluoromethyl)-3-fluorobenzene; 4-Chloro-2-fluoro-α,α-difluorotoluene; 3-Fluoro-4-chlorobenzylidene difluoride; (4-Chloro-2-fluorophenyl)difluoromethane; Benzene, 4-chloro-1-(difluoromethyl)-2-fluoro-; α,α-Difluoro-4-chloro-2-fluorotoluene
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(Difluoromethyl)-2-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reactive metals. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.