Description

4-(Difluoromethoxy)-2-Fluoro-1-Methyl-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy and fluoro substituents make it a valuable intermediate for creating molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing metabolically stable difluoromethoxy groups.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a fluorinated core structure in the synthesis of electronic materials for displays and organic light-emitting diodes.
• Polymer Modification: Employed to incorporate fluorine into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other transformations to construct complex fluorinated architectures.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Fluoro-1-Methyl-Benzene
CAS No.	1214337-06-0
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	2-Fluoro-4-(difluoromethoxy)-1-methylbenzene; 1-Methyl-2-fluoro-4-(difluoromethoxy)benzene; 4-(Difluoromethoxy)-2-fluoro-1-methylbenzene; 2-Fluoro-α,α-difluoro-4-methylanisole; 1-Fluoro-2-methyl-5-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Fluoro-1-Methyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.