Description

Ethyl 3-Bromo-5-Fluoroisonicotinate is a high-purity fluorinated and brominated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its dual halogen functionality, which provides distinct reactive sites for selective cross-coupling and functionalization reactions. It is primarily sought after by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: An essential substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromine substituent.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated pyridine cores.

Basic Information

Product Name	Ethyl 3-Bromo-5-Fluoroisonicotinate
CAS No.	1214335-25-7
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	Ethyl 3-bromo-5-fluoropyridine-4-carboxylate; 5-Fluoro-3-bromoisonicotinic acid ethyl ester; 3-Bromo-5-fluoro-4-pyridinecarboxylic acid ethyl ester; 4-Pyridinecarboxylic acid, 3-bromo-5-fluoro-, ethyl ester; Ethyl 5-fluoro-3-bromoisonicotinate; Isonicotinic acid, 3-bromo-5-fluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-Bromo-5-Fluoroisonicotinate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.