Description

4-(Difluoromethyl)-2-Fluoro-1-Methylbenzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine and difluoromethyl groups, which are crucial for modulating the physicochemical properties of target molecules, such as metabolic stability, lipophilicity, and bioavailability. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for introducing fluorine motifs into drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorination enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials due to its electron-withdrawing characteristics.
• Advanced Polymer Chemistry: Acts as a monomer or modifier for creating specialty fluoropolymers with unique thermal, chemical, and surface properties.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex molecular architectures in academic and industrial labs.

Basic Information

Product Name	4-(Difluoromethyl)-2-Fluoro-1-Methylbenzene
CAS No.	1214334-21-0
Molecular Formula	C8H7F3
Molecular Weight	160.14 g/mol
Synonyms	2-Fluoro-α,α-difluoro-p-xylene; 1-(Difluoromethyl)-2-fluoro-4-methylbenzene; 2-Fluoro-4-methylbenzylidene difluoride; 4-Methyl-2-fluorobenzylidene difluoride; 2-Fluoro-4-(difluoromethyl)toluene; Benzene, 4-(difluoromethyl)-2-fluoro-1-methyl-; p-Xylene, 2-fluoro-α,α-difluoro-
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)-2-Fluoro-1-Methylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.