Description

1-Chloro-4-(Difluoromethyl)-2-Fluorobenzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring chlorine and fluorine substituents, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Serves as a versatile building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs) due to its electronic properties.
• Polymer & Resin Modifier: Incorporated as a monomer or additive to impart specific characteristics like chemical resistance, thermal stability, or low surface energy to advanced polymers.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a ligand precursor in organometallic catalysis.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated arenes.

Basic Information

Product Name	1-Chloro-4-(Difluoromethyl)-2-Fluorobenzene
CAS No.	1214333-76-2
Molecular Formula	C7H4ClF3
Molecular Weight	180.56 g/mol
Synonyms	2-Fluoro-1-chloro-4-(difluoromethyl)benzene; 4-Chloro-3-fluorobenzylidene Difluoride; 1-Chloro-2-fluoro-4-(difluoromethyl)benzene; Benzene, 1-chloro-4-(difluoromethyl)-2-fluoro-; (Difluoromethyl)-2-fluorochlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-(Difluoromethyl)-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure it meets the highest standards of purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.