Description

1-(Difluoromethoxy)-3-Fluoro-2-Methyl-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique chemical structure, which incorporates both difluoromethoxy and fluoro substituents, enabling precise modulation of electronic and steric properties in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where fluorination is a key strategy to enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, contributing to improved charge transport and thermal stability in display technologies.
• Polymer Modification: Employed to introduce fluorine into polymer backbones or side chains, enhancing material properties such as chemical resistance, weatherability, and dielectric performance.
• Radiotracer Development: The presence of fluorine-19 makes it a potential candidate for use in the synthesis of precursors for Positron Emission Tomography (PET) imaging agents.
• General Fluorination Chemistry: Acts as a versatile reagent in medicinal and synthetic chemistry for introducing fluorinated motifs via cross-coupling or nucleophilic substitution reactions.

Basic Information

Product Name	1-(Difluoromethoxy)-3-Fluoro-2-Methyl-Benzene
CAS No.	1214333-52-4
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	3-Fluoro-2-methyl-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-3-fluoro-2-methylbenzene; 2-Methyl-3-fluoroanisole, α,α-difluoro; Benzene, 1-(difluoromethoxy)-3-fluoro-2-methyl-; o-Cresol, 3-fluoro-, difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-3-Fluoro-2-Methyl-Benzene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting R&D and scale-up requirements. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and quality assurance for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.