Description

2-(Difluoromethoxy)-4-Fluoro-1-Methyl-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoromethoxy and fluoro substituents, which are critical for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of new drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Active Ingredient Development: Used to construct novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity, stability, and lipophilicity.
• Liquid Crystal & OLED Material Research: Serves as a precursor in the development of fluorinated organic electronic materials due to its ability to influence molecular polarity and packing.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions to introduce complex fluorinated motifs.

Basic Information

Item	Detail
Product Name	2-(Difluoromethoxy)-4-Fluoro-1-Methyl-Benzene
CAS No.	1214333-40-0
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	4-Fluoro-2-(difluoromethoxy)-1-methylbenzene; 1-Methyl-2-(difluoromethoxy)-4-fluorobenzene; 2-(Difluoromethoxy)-4-fluorotoluene; 4-Fluoro-α,α-difluoro-o-cresol methyl ether; DFMFB (abbreviation); o-Cresol, 4-fluoro-, difluoromethyl ether
EINECS	Contact for details

Quality Control

Our production of 2-(Difluoromethoxy)-4-Fluoro-1-Methyl-Benzene adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.