Description

4-Trifluoromethylnicotinic Acid Ethyl Ester is a high-value fluorinated nicotinate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, enhancing their biological activity and physicochemical profile. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group improves efficacy and environmental stability.
• Material Science Research: Serves as a precursor for fluorinated liquid crystals, organic semiconductors, and specialty polymers.
• Chemical Biology Probes: Employed in the design of labeled compounds and molecular probes for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a fluorinated pyridine moiety.

Basic Information

Product Name	4-Trifluoromethylnicotinic Acid Ethyl Ester
CAS No.	1214332-65-6
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	Ethyl 4-(trifluoromethyl)nicotinate; Ethyl 4-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 4-(trifluoromethyl)-, ethyl ester; 4-Trifluoromethyl-3-pyridinecarboxylic acid ethyl ester; 4-(Trifluoromethyl)nicotinic acid ethyl ester; Nicotinic acid, 4-trifluoromethyl-, ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylnicotinic Acid Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available for every batch upon request, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.