Description

2-Fluoro-3-Trifluoromethyltoluene is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. This compound is prized for its unique trifluoromethyl and fluorine substituents, which impart significant lipophilicity and metabolic stability to target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine atoms to modulate bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Material Development: Employed in creating specialty polymers, coatings, and advanced materials with tailored surface properties and chemical resistance.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations for constructing complex molecular architectures.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for studying structure-activity relationships (SAR) and new fluorination methodologies.

Basic Information

Product Name	2-Fluoro-3-Trifluoromethyltoluene
CAS No.	1214331-63-1
Molecular Formula	C8H6F4
Molecular Weight	178.13 g/mol
Synonyms	1-Fluoro-2-methyl-3-(trifluoromethyl)benzene; 2-Methyl-α,α,α,6-tetrafluorotoluene; 3-(Trifluoromethyl)-2-fluorotoluene; 2-Fluoro-α,α,α-trifluoro-m-xylene; 2-Fluoro-3-(trifluoromethyl)methylbenzene; 2-Fluoro-3-(trifluoromethyl)toluene; 3-Trifluoromethyl-2-fluorotoluene; m-Xylene, 2-fluoro-α,α,α-trifluoro-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Trifluoromethyltoluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to its fluoride/strong alkali chemical property, ensure it is stored separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.