Description

2,5-Difluoropyridine-4-Carbonitrile is a high-value fluorinated pyridine derivative and a versatile chemical building block. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries requiring advanced heterocyclic chemistry, such as medicinal chemistry for drug discovery and crop protection research, need this specialized nitrile for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoropyridine moiety can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as electron-transport layers or components for organic light-emitting diodes (OLEDs).
• Fluorinated Liquid Crystal Synthesis: Acts as a key intermediate for creating fluorinated aromatic cores used in high-performance liquid crystal displays (LCDs).
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2,5-Difluoropyridine-4-Carbonitrile
CAS No.	1214331-33-5
Molecular Formula	C6H2F2N2
Molecular Weight	140.09 g/mol
Synonyms	4-Cyano-2,5-difluoropyridine; 2,5-Difluoro-4-pyridinecarbonitrile; 2,5-Difluoropyridine-4-carbonitrile; 2,5-Difluoroisonicotinonitrile; 4-Pyridinecarbonitrile, 2,5-difluoro-; 2,5-Difluoro-4-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2,5-Difluoropyridine-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive and reactive with strong bases; ensure the container is kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.