Description

2-Difluoromethoxy-5-(Trifluoromethyl)Pyridine is a high-value, multi-fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique structural motif, combining a difluoromethoxy group with a trifluoromethyl substituent on the pyridine ring, which is instrumental in modulating the physicochemical and biological properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where the introduction of fluorine atoms is a key strategy to enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the design and production of next-generation herbicides, fungicides, and insecticides, where the fluorine groups contribute to improved environmental stability and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalysis and metal-organic frameworks (MOFs) due to its electron-deficient pyridine core.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, such as electron-transport layers or fluorinated polymers, where its structure can influence electronic properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Difluoromethoxy-5-(Trifluoromethyl)Pyridine
CAS No.	1214328-65-0
Molecular Formula	C7H4F5NO
Molecular Weight	213.11 g/mol
Synonyms	5-(Trifluoromethyl)-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-(trifluoromethyl)pyridine; Pyridine, 2-(difluoromethoxy)-5-(trifluoromethyl)-; 1214328-65-0; 2-Difluoromethoxy-5-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxy-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency, traceability, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.