Description

2-(Difluoromethoxy)-5-Fluorobenzaldehyde is a high-purity fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy and fluorine substituents make it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Functional Material Development: Employed in organic synthesis for creating specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Fluorobenzaldehyde
CAS No.	1214326-36-9
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	5-Fluoro-2-(difluoromethoxy)benzaldehyde; 2-(Difluoromethoxy)-5-fluorobenzenecarboxaldehyde; 5-Fluoro-α,α-difluoroanisole-2-carboxaldehyde; Benzaldehyde, 2-(difluoromethoxy)-5-fluoro-; 1214326-36-9
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-5-Fluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and ensures reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.