Description

(R)-2-Amino-2-(3,5-Difluoropyridin-2-Yl)Ethanol is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical research and development. Its core value lies in its unique stereochemistry and difluoropyridine moiety, which are critical for imparting desirable metabolic stability and binding affinity in active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists working in the synthesis of novel therapeutics, particularly in areas such as kinase inhibitors and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting protein kinases.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical precursor in the research and process development of new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized as a chiral auxiliary or resolving agent in stereoselective chemical transformations.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Used in the development of robust, scalable synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	(R)-2-Amino-2-(3,5-Difluoropyridin-2-Yl)Ethanol
CAS No.	1213009-73-4
Molecular Formula	C7H8F2N2O
Molecular Weight	174.15 g/mol
Synonyms	(R)-2-Amino-2-(3,5-difluoropyridin-2-yl)ethan-1-ol; (R)-2-(3,5-Difluoropyridin-2-yl)-2-aminoethanol; (R)-2-(3,5-Difluoro-2-pyridinyl)-2-aminoethanol; (R)-1-(3,5-Difluoropyridin-2-yl)-2-aminoethanol; (2R)-2-Amino-2-(3,5-difluoropyridin-2-yl)ethanol; (R)-2-(3,5-Difluoropyridin-2-yl)glycinol; (R)-Amino(3,5-difluoropyridin-2-yl)methanol
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-2-(3,5-Difluoropyridin-2-Yl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.