Description

n-Cbz-trans-4-Fluoro-L-Prolinonitrile is a high-value, fluorinated proline derivative designed for advanced pharmaceutical research and synthesis. This compound serves as a critical chiral building block for the development of novel therapeutic agents, particularly protease inhibitors and other bioactive molecules. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting proteases like DPP-4.
• Peptidomimetic Research: Used to incorporate fluorinated proline motifs into peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by introducing fluorine atoms to modulate electronic properties and conformation.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: The Cbz-protected amine and nitrile group offer handles for further chemical modification in probe and linker synthesis.

Basic Information

Product Name	n-Cbz-trans-4-Fluoro-L-Prolinonitrile
CAS No.	1212342-08-9
Molecular Formula	C₁₄H₁₅FN₂O₂
Molecular Weight	262.28 g/mol
Synonyms	(2S,4R)-1-[(Benzyloxy)carbonyl]-4-fluoropyrrolidine-2-carbonitrile; (2S,4R)-N-Carbobenzoxy-4-fluoro-L-prolinonitrile; trans-4-Fluoro-N-Cbz-L-prolinonitrile; (2S,4R)-4-Fluoro-1-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonitrile; N-[(Benzyloxy)carbonyl]-trans-4-fluoro-L-prolinonitrile; N-Cbz-trans-4-Fluoro-L-Prolinonitrile; Benzyl (2S,4R)-2-cyano-4-fluoropyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our n-Cbz-trans-4-Fluoro-L-Prolinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.