Description

(R)-Mg132 CAS NO 1211877-36-9 is a potent and enantiomerically pure proteasome inhibitor, specifically targeting the chymotrypsin-like activity. This compound is a critical research tool for studying cellular protein degradation pathways, apoptosis, and the role of the ubiquitin-proteasome system in disease. It is essential for researchers and developers in the fields of pharmaceutical R&D, biochemistry, and molecular biology, particularly for investigating cancer, neurodegenerative disorders, and inflammatory conditions.

Application

• Biomedical Research: A key reagent for studying proteasome function, protein turnover, and ubiquitin-proteasome system (UPS) dynamics in cell cultures and animal models.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and target validation for diseases like cancer and inflammation.
• Mechanistic Studies: Investigating the molecular pathways of apoptosis (programmed cell death) and cellular stress responses.
• Neurodegenerative Disease Research: Exploring the accumulation of misfolded proteins in conditions such as Alzheimer's and Parkinson's disease.
• Signal Transduction Analysis: Used to dissect the role of specific protein degradation in various signaling cascades.
• Academic & Institutional Laboratories: A standard compound for graduate-level research and advanced studies in biochemistry and cell biology.

Basic Information

Product Name	(R)-Mg132
CAS No.	1211877-36-9
Molecular Formula	C₂₆H₄₁N₃O₅
Molecular Weight	475.63 g/mol
Synonyms	(R)-MG-132; (R)-Z-Leu-Leu-Leu-al; (R)-Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; (R)-Z-LLL-al; (R)-Z-Leu-Leu-Leucinal; (R)-Enantiomer of MG132; Proteasome Inhibitor (R)-MG132; (R)-Benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
EINECS	Contact for details

Quality Control

Our (R)-Mg132 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.