Description

4-Chloro-5-(Trifluoromethyl)-Pyridine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its core value lies in the strategic combination of a carboxylic acid handle, a chloro substituent, and a trifluoromethyl group, enabling precise molecular modifications. This compound is critically needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Serves as a versatile precursor for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Used in the synthesis of specialized pyridine-based ligands for metal catalysis and coordination chemistry applications.
• Material Science Research: Employed as a monomer or functionalizing agent in the creation of advanced polymers and functional materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloro-5-(Trifluoromethyl)-Pyridine-2-Carboxylic Acid
CAS No.	1211591-26-2
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	2-Pyridinecarboxylic acid, 4-chloro-5-(trifluoromethyl)-; 4-Chloro-5-trifluoromethylpicolinic acid; 4-Chloro-5-(trifluoromethyl)picolinic acid; 4-Chloro-5-(trifluoromethyl)-2-pyridinecarboxylic acid; 4-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid; 2-Carboxy-4-chloro-5-trifluoromethylpyridine; 1211591-26-2
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-5-(Trifluoromethyl)-Pyridine-2-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. Certificates of Analysis (COA) documenting all specifications are provided with every shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.