Description

2-(Difluoromethoxy)Pyridine-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its pyridine core and difluoromethoxy substituent. This compound is essential for medicinal chemistry research and development, offering a unique structural motif for modulating the physicochemical and pharmacokinetic properties of target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for constructing specialized ligands in catalytic systems or as a component in metal-organic frameworks (MOFs).
• Material Science Research: Incorporated into the design of specialty polymers and organic electronic materials to fine-tune electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Item	Detail
Product Name	2-(Difluoromethoxy)Pyridine-3-Carboxylic Acid
CAS No.	1211587-59-5
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	2-(Difluoromethoxy)nicotinic acid; 3-Pyridinecarboxylic acid, 2-(difluoromethoxy)-; 2-(Difluoromethoxy)-3-pyridinecarboxylic acid; 2-Difluoromethoxynicotinic acid; Nicotinic acid, 2-(difluoromethoxy)-; 1211587-59-5; 2-(Difluoromethoxy)pyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 2-(Difluoromethoxy)Pyridine-3-Carboxylic Acid adheres to stringent quality management protocols. Each batch is analytically verified using advanced techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality system is designed to support applications requiring high-purity intermediates, and we can accommodate specific customer requirements for analytical methods or impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.