Description

5-Fluoro-6-Methylpyridin-3-Ol is a high-purity fluorinated pyridine derivative, a key building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific substitution pattern is critical for modulating biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or organic semiconductors, where fluorinated aromatics are valuable.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluoropyridine scaffolds.

Basic Information

Product Name	5-Fluoro-6-Methylpyridin-3-Ol
CAS No.	1211584-44-9
Molecular Formula	C6H6FNO
Molecular Weight	127.12 g/mol
Synonyms	3-Hydroxy-5-fluoro-6-methylpyridine; 5-Fluoro-6-methyl-3-pyridinol; 5-Fluoro-6-methyl-3-hydroxypyridine; 6-Methyl-5-fluoropyridin-3-ol; 5-Fluoro-6-methyl-3-pyridinone (tautomer); 5-Fluoro-6-methylpyridin-3(1H)-one; 5-Fluoro-6-methyl-3(1H)-pyridinone
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Methylpyridin-3-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.