Description

5-Difluoromethyl-Pyridine-3-Carbaldehyde is a high-purity fluorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique reactivity imparted by the difluoromethyl and aldehyde functional groups, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands, organocatalysts, and metal-organic frameworks (MOFs) used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Utilized to develop fluorescent tags, enzyme inhibitors, and other molecular probes for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	5-Difluoromethyl-Pyridine-3-Carbaldehyde
CAS No.	1211583-76-4
Molecular Formula	C7H5F2NO
Molecular Weight	157.12 g/mol
Synonyms	3-Pyridinecarboxaldehyde, 5-(difluoromethyl)-; 5-(Difluoromethyl)nicotinaldehyde; 5-(Difluoromethyl)pyridine-3-carboxaldehyde; Nicotinaldehyde, 5-(difluoromethyl)-; Pyridine-3-carbaldehyde, 5-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 5-Difluoromethyl-Pyridine-3-Carbaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), identity confirmation, and impurity profile is supplied with each shipment. Our quality protocols are designed to support cGMP and ISO standards for reliable, batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.