Description

3-Bromo-4-Chloro-5-Fluoropyridine is a high-value halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the introduction of multiple halogen atoms to modulate the biological activity and physicochemical properties of target molecules. It is primarily utilized by pharmaceutical and agrochemical R&D teams for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen pattern influences bioactivity.
• Material Science Precursor: Serves as a building block for functionalized ligands, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Nucleophilic Aromatic Substitution: The halogen atoms provide sites for selective displacement with various nucleophiles to create diverse pyridine libraries.

Basic Information

Product Name	3-Bromo-4-Chloro-5-Fluoropyridine
CAS No.	1211540-92-9
Molecular Formula	C5H2BrClFN
Molecular Weight	210.43 g/mol
Synonyms	3-Bromo-4-chloro-5-fluoropyridine; 5-Fluoro-3-bromo-4-chloropyridine; 4-Chloro-3-bromo-5-fluoropyridine; Pyridine, 3-bromo-4-chloro-5-fluoro-; 1211540-92-9; SCHEMBL21883027; BRN 12617247
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Chloro-5-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.