Description

2-(Difluoromethyl)Pyridine-4-Carboxaldehyde, also known as 2-(Difluoromethyl)-4-formylpyridine, is a versatile and high-value fluorinated pyridine derivative. This compound serves as a critical pharmaceutical intermediate and organic building block for synthesizing complex molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoromethyl and aldehyde groups impart unique biological activity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and liquid crystals for electronic and optical applications.
• Chemical Biology Probes: Utilized to create fluorinated probes and tags for studying biological mechanisms and protein interactions.
• Cross-Coupling Reactions: The formyl group is a versatile handle for further functionalization via reactions like reductive amination or condensation.

Basic Information

Product Name	2-(Difluoromethyl)Pyridine-4-Carboxaldehyde
CAS No.	1211540-67-8
Molecular Formula	C7H5F2NO
Molecular Weight	157.12 g/mol
Synonyms	2-(Difluoromethyl)-4-formylpyridine; 4-Formyl-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)isonicotinaldehyde; 2-(Difluoromethyl)-4-pyridinecarboxaldehyde; Pyridine-4-carboxaldehyde, 2-(difluoromethyl)-; 1211540-67-8; 2-Difluoromethylpyridine-4-carbaldehyde
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)Pyridine-4-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.