Description

2-Bromo-3-Hydroxy-5-Trifluoromethylpyridine is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its unique structure, featuring bromine, hydroxyl, and trifluoromethyl substituents on a pyridine core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific halogenated or fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-3-Hydroxy-5-Trifluoromethylpyridine
CAS No.	1211537-52-8
Molecular Formula	C6H3BrF3NO
Molecular Weight	241.99 g/mol
Synonyms	5-(Trifluoromethyl)-3-hydroxy-2-bromopyridine; 2-Bromo-5-(trifluoromethyl)pyridin-3-ol; 3-Hydroxy-2-bromo-5-trifluoromethylpyridine; 2-Bromo-3-hydroxy-5-(trifluoromethyl)pyridine; 2-Bromo-5-trifluoromethyl-3-pyridinol
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Hydroxy-5-Trifluoromethylpyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic route. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by validated methods (HPLC, GC, NMR) is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.