Description

6-Bromo-2-Fluoro-3-Methylpyridine CAS NO 1211536-81-0 is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for introducing specific bromo and fluoro substituents, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in kinase inhibitor and central nervous system (CNS) active molecule research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the halogenated pyridine core imparts specific biological activity.
• Material Science Precursor: Serves as a starting material for synthesizing functionalized ligands used in catalysis and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry Building Block: The fluorine substituent provides metabolic stability and influences lipophilicity, making it valuable for medicinal chemistry optimization programs.

Basic Information

Product Name	6-Bromo-2-Fluoro-3-Methylpyridine
CAS No.	1211536-81-0
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	2-Fluoro-3-methyl-6-bromopyridine; 6-Bromo-2-fluoro-3-picoline; 3-Methyl-6-bromo-2-fluoropyridine; 2-Fluoro-6-bromo-3-methylpyridine; Pyridine, 6-bromo-2-fluoro-3-methyl-; Bromofluoromethylpyridine (unspecified isomer); Building block 1211536-81-0
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Fluoro-3-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.