Description

6-(1,1-Difluoroethyl)Pyridine-2-Carboxylic Acid is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a difluoroethyl moiety with a carboxylic acid functional group on a pyridine core, enabling precise modifications in complex molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in the development of new drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for constructing specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of functionalized organic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to develop molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific fluorinated heterocyclic structures.

Basic Information

Product Name	6-(1,1-Difluoroethyl)Pyridine-2-Carboxylic Acid
CAS No.	1211529-86-0
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	2-Pyridinecarboxylic acid, 6-(1,1-difluoroethyl)-; 6-(1,1-Difluoroethyl)picolinic acid; 6-(Difluoroethyl)pyridine-2-carboxylic acid; 2-Carboxy-6-(1,1-difluoroethyl)pyridine; 6-(1,1-Difluoroethyl)-2-pyridinecarboxylic acid; 1211529-86-0; 6-(α,α-Difluoroethyl)picolinic acid
EINECS	Contact for details

Quality Control

Our 6-(1,1-Difluoroethyl)Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.