Description

2,4-Difluoropyridimine is a high-value fluorinated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoropyrimidine scaffold is essential for modulating the physicochemical and metabolic properties of target molecules, making it a sought-after intermediate. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Serves as a precursor for functionalized polymers, liquid crystals, and electronic materials requiring specific fluorine-based properties.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and diagnostic agents due to its ability to act as a bioisostere.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2,4-Difluoropyridimine
CAS No.	1211528-95-8
Molecular Formula	C5H3F2N3
Molecular Weight	143.09 g/mol
Synonyms	2,4-Difluoropyrimidine; Pyrimidine, 2,4-difluoro-; 2,4-Difluoro-1,3-diazine; 2,4-Difluoropyrimidine (principal synonym); 2,4-Difluoro-pyrimidine; 2,4-Difluor-1,3-diazin; 2,4-Difluoropyrimidin; 1211528-95-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2,4-Difluoropyridimine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as verified by advanced analytical techniques (HPLC, GC, NMR, MS). Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.