Description

2-Bromo-3-Fluoropyridin-4-Ol is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to bioactivity and metabolic stability.
• Material Science Research: Employed as a precursor for synthesizing functionalized ligands, organic electronic materials, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Serves as a versatile handle for creating fluorescent tags, photoaffinity labels, and other molecular probes for biological target identification.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, and Buchwald-Hartwig aminations.

Basic Information

Product Name	2-Bromo-3-Fluoropyridin-4-Ol
CAS No.	1211525-92-6
Molecular Formula	C5H3BrFNO
Molecular Weight	191.99 g/mol
Synonyms	4-Hydroxy-2-bromo-3-fluoropyridine; 3-Fluoro-2-bromopyridin-4-ol; 2-Bromo-3-fluoro-4-hydroxypyridine; 2-Bromo-3-fluoro-4-pyridinol; 4-Pyridinol, 2-bromo-3-fluoro-; 2-Bromo-3-fluoropyridin-4-ol; 3-Fluoro-2-bromo-4-pyridinol
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Fluoropyridin-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.