Description

3-Bromo-5-Nitrobenzene-1-Sulfonyl Chloride is a versatile and highly reactive aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual functionality, where the sulfonyl chloride group acts as an excellent electrophile for sulfonamide formation, and the bromo and nitro substituents provide orthogonal handles for further functionalization via cross-coupling or reduction reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for creating sulfonamide-based drug candidates and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel sulfonamide-based drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides with sulfonamide moieties.
• Material Science Research: Used in the creation of specialty polymers and functional materials requiring aromatic sulfonyl groups.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and labeling of biomolecules.
• Dye & Pigment Industry: Intermediate in the synthesis of complex, high-performance colorants and photographic chemicals.
• Cross-Coupling Substrate: The bromo substituent enables further elaboration via palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination.

Basic Information

Product Name	3-Bromo-5-Nitrobenzene-1-Sulfonyl Chloride
CAS No.	1211517-87-1
Molecular Formula	C6H3BrClNO4S
Molecular Weight	300.52 g/mol
Synonyms	3-Bromo-5-nitrobenzenesulfonyl chloride; 1-Bromo-3-nitro-5-(chlorosulfonyl)benzene; Benzenesulfonyl chloride, 3-bromo-5-nitro-; 5-Bromo-3-nitrobenzenesulfonyl chloride; 3-Bromo-5-nitrobenzene sulfonyl chloride; 3-Bromo-5-nitrobenzenesulphonyl chloride; 3-Bromo-5-nitro-phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Nitrobenzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, amines, and moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.