Description

2-Bromo-5-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for facilitating complex molecular transformations in advanced synthetic chemistry, offering precise reactivity for constructing sophisticated target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Functional Group Transformation: The carboxylic acid group allows for further derivatization into amides, esters, and other functional groups, expanding its utility in library synthesis.

Basic Information

Product Name	2-Bromo-5-(Trifluoromethyl)Nicotinic Acid
CAS No.	1211515-81-9
Molecular Formula	C7H3BrF3NO2
Molecular Weight	269.99 g/mol
Synonyms	2-Bromo-5-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Bromo-6-(trifluoromethyl)pyridine-2-carboxylic acid; Nicotinic acid, 2-bromo-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-bromonicotinic acid; 2-Bromo-5-trifluoromethylnicotinic acid; 2-Bromo-5-trifluoromethyl-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.