Description

5-Chloro-3-Fluoropicoline is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes in diagnostic and imaging applications.

Basic Information

Product Name	5-Chloro-3-Fluoropicoline
CAS No.	1210868-68-0
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	3-Fluoro-5-chloropicoline; 5-Chloro-3-fluoro-2-methylpyridine; 2-Methyl-5-chloro-3-fluoropyridine; 5-Chloro-3-fluoro-2-picoline; 2-Picoline, 5-chloro-3-fluoro-; 5-Chloro-3-fluor-2-methylpyridin (German); 5-クロロ-3-フルオロ-2-ピコリン (Japanese)
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Fluoropicoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.