Description

2-Bromo-5-Fluoropyrazine is a high-value halogenated pyrazine building block essential for modern synthetic chemistry. This compound is prized for its dual functionality, offering reactive sites for cross-coupling and nucleophilic substitution reactions to create complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the pyrazine core's bioactivity.
• Material Science Research: Serves as a precursor for the synthesis of functionalized heterocyclic compounds used in organic electronics and ligand design.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi couplings to introduce the pyrazine moiety into more complex systems.
• Nucleophilic Aromatic Substitution: The fluorine and bromine atoms provide orthogonal reactivity for sequential functionalization.
• Chemical Library Development: Used in high-throughput and combinatorial chemistry for drug discovery and lead optimization.

Basic Information

Product Name	2-Bromo-5-Fluoropyrazine
CAS No.	1209459-10-8
Molecular Formula	C4H2BrFN2
Molecular Weight	176.97 g/mol
Synonyms	5-Fluoro-2-bromopyrazine; 2-Bromo-5-fluoropyrazine; 5-Fluoropyrazin-2-yl bromide; Fluoropyrazine bromide; Pyrazine, 2-bromo-5-fluoro-; Bromofluoropyrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluoropyrazine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.