Description

4-Bromo-2-Fluoropyrimidine is a high-purity halogenated pyrimidine building block essential for advanced organic synthesis. This compound is valued for its dual reactive sites, which facilitate selective cross-coupling and nucleophilic substitution reactions, enabling the rapid construction of complex heterocyclic scaffolds. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and antiviral drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and other crop protection chemicals.
• Material Science Research: Serves as a precursor for creating functionalized organic materials and liquid crystals.
• Cross-Coupling Reactions: Utilized in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce the pyrimidine core into more complex molecules.
• Nucleophilic Aromatic Substitution: The fluorine and bromine substituents allow for sequential, selective substitution to create diverse pyrimidine libraries.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes.

Basic Information

Product Name	4-Bromo-2-Fluoropyrimidine
CAS No.	1209458-22-9
Molecular Formula	C4H2BrFN2
Molecular Weight	176.97 g/mol
Synonyms	2-Fluoro-4-bromopyrimidine; 4-Bromo-2-fluoropyrimidine; Pyrimidine, 4-bromo-2-fluoro-; 1209458-22-9; 4-Bromo-2-fluoro-1,3-diazine; 2-Fluoro-4-bromo-1,3-diazine; 4-Bromo-2-fluoropyrimidine (CAS 1209458-22-9)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.