Description

2-Chloro-5-Trifluoromethyl-Pyridine-3-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate essential for advanced synthesis. Its core value lies in its dual reactive sites—the sulfonyl chloride and halogenated pyridine ring—which enable precise molecular construction in complex chemical processes. This compound is critically needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly for crop protection and pharmaceutical candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Crucial precursor for manufacturing advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethylpyridine moiety for enhanced bioactivity and environmental stability.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and advanced organic electronic materials due to its unique electronic properties.
• Chemical Derivatization: Serves as a versatile reagent for introducing the sulfonyl chloride functional group into complex molecules for further chemical modification or conjugation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in fluorinated heterocycles.

Basic Information

Item	Details
Product Name	2-Chloro-5-Trifluoromethyl-Pyridine-3-Sulfonyl Chloride
CAS No.	1208081-79-1
Molecular Formula	C7H2Cl2F3NO2S
Molecular Weight	304.06 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride, 2-chloro-5-(trifluoromethyl)-; 2-Chloro-5-trifluoromethyl-3-pyridinesulfonyl chloride; 2-Chloro-α,α,α-trifluoro-3-pyridinesulfonyl chloride; 5-Trifluoromethyl-2-chloropyridine-3-sulfonyl chloride; 2-Chloro-5-trifluoromethylpyridine-3-sulfonylchloride; 2-Chloro-5-(trifluoromethyl)-3-pyridinesulfonylchloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Trifluoromethyl-Pyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with global regulatory frameworks, and our quality commitment is designed to meet the stringent requirements of pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.