Description

1,2-Difluoro-4-Iodo-3-Methylbenzene is a high-purity, multi-substituted aromatic building block of significant interest in advanced organic synthesis. Its unique combination of fluorine and iodine substituents on the benzene ring makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications requiring precise structural modification and functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine and iodine atoms to modulate bioavailability, metabolic stability, and receptor binding.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and iodo groups can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for creating advanced organic electronic materials and liquid crystal molecules due to its halogenated aromatic structure.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck), enabling the formation of new carbon-carbon bonds.
• Fluorination & Functionalization Studies: Used as a model compound or starting material in methodological research for selective fluorination and further functional group transformations.
• Ligand & Catalyst Development: Can be incorporated into the structure of specialized ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	1,2-Difluoro-4-Iodo-3-Methylbenzene
CAS No.	1208078-20-9
Molecular Formula	C7H5F2I
Molecular Weight	253.92 g/mol
Synonyms	3-Methyl-1,2-difluoro-4-iodobenzene; 4-Iodo-1,2-difluoro-3-methylbenzene; 1,2-Difluoro-3-methyl-4-iodobenzene; 3-Methyl-4-iodo-1,2-difluorobenzene; Benzene, 1,2-difluoro-4-iodo-3-methyl-
EINECS	Contact for details

Quality Control

Every batch of 1,2-Difluoro-4-Iodo-3-Methylbenzene is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality systems support compliance with cGMP and ISO standards for reliable sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.